Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 13, 2019BioMedical Engineering OnLineOpen Access

Heart defibrillation: relationship between pacing threshold and defibrillation probability

View Full Paper
Ask AI
Bookmark
Share

Key result

In isolated rat hearts, 0.5-ms defibrillatory pulses had a significantly lower ratio of defibrillation probability to pacing threshold (17.65) compared to other durations, indicating improved safety.

Why the study?

Because defibrillation therapy causes critical side effects on cardiac tissue, optimizing defibrillation parameters is desirable to increase efficiency.

Does varying the pulse duration of defibrillatory shocks improve the ratio of defibrillation probability to pacing threshold in isolated rat hearts?

Comparison

Different stimuli durations

Authors

PAPriscila Correia AntoneliUniversidade Federal de São PauloJGJair Trapé GoulartUniversidade de BrasíliaIBIsabella BonilhaUniversidade Estadual de Campinas (UNICAMP)

Discussion

Loading...

Member takes

Implication

Pulse duration optimization merits preclinical study in defibrillation; leaves open translation beyond isolated rat hearts.

Structured PICO

Does varying the pulse duration of defibrillatory shocks improve the ratio of defibrillation probability to pacing threshold in isolated rat hearts?

P
Population
10 adult male Wistar rats (age 5-6 months) with isolated heart preparation (Langendorff).
I
Intervention
Defibrillatory shocks with varying pulse durations (0.2, 0.5, 1, 3, 5, 8, and 10 ms).
C
Comparator
Comparison across the different pulse durations within the same hearts.
O
Outcome
Ratio of defibrillation probability (HEF50) to pacing threshold (ET).surrogate

Main Result

p-value: p=<0.001

In an isolated rat heart model, 0.5-ms defibrillatory pulses optimized the ratio of defibrillation probability to pacing threshold, suggesting a potential parameter to improve defibrillator safety and efficiency.

Limitations

  • Time between heart removal and cannulation finalization (30 s)
  • Contractile and chronotropic impairment due to prolonged experiment time and cumulative effect of consecutive shocks
  • Results from rodent models cannot be directly related to the clinical context
  • Contractile and chronotropic impairment may be present due to prolonged experiment time and cumulative effect of consecutive shocks
  • Rodent model results cannot be directly related to the clinical context

Cite This Study

Antoneli et al. (2019) studied Ventricular fibrillation (n=10). 0.5-ms defibrillatory pulse vs. Other pulse durations (0.2, 1, 3, 5, 8, 10 ms) was evaluated on Ratio of defibrillation probability (HEF50) to pacing threshold (p=<0.001). In isolated rat hearts, 0.5-ms defibrillatory pulses had a significantly lower ratio of defibrillation probability to pacing threshold (17.65) compared to other durations, indicating improved safety.

synapsesocial.com/papers/6a191b5bf3c200df1057e01ahttps://doi.org/10.1186/s12938-019-0715-5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation Among Fibrillation, Defibrillation, and Cardiac Pacing1995 · 38 citations
  2. 2Ventricular Fibrillation: Mechanisms of Initiation and Maintenance2000 · 382 citations
  3. 3Excitability of Isolated Hearts from Rats During Postnatal Development2002 · 14 citations
  4. 4Small Animal Models of Heart Failure2009 · 262 citations
  5. 5Ventricular myocyte injury by high-intensity electric field: Effect of pulse duration2016 · 26 citations