The low frequency isoform of platelet GPVI (VIb) acts as a natural regulator that dampens platelet reactivity.
The search is on for natural regulators of platelet reactivity. In this issue of Blood, Trifiro and colleagues confirm that the low frequency isoform of platelet GPVI (VIb) attenuates ligand-mediated signal transduction and dampens down platelet reactivity with collagen while not affecting GPVI receptor copy number.
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Alan T. Nurden (2009) studied this question.
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