Differential Requirement for the Nonhelical Tailpiece and the C Terminus of the Myosin Rod inCaenorhabditis elegansMuscle

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Population

Caenorhabditis elegans striated muscle (animals lacking full-length myosin heavy chain)

Comparison

Myosin heavy chain constructs with removed or… vs Wild type or endogenous myosin heavy chain

Design

Preclinical

Authors

Discussion

Distinguishes essential myosin domains for embryonic muscle function; extends developmental insights but leaves open mammalian cardiac translation.

Population

Caenorhabditis elegans striated muscle (animals lacking full-length myosin heavy chain)

Intervention

Myosin heavy chain constructs with removed or mutated residues in the C-terminal domains (end of the coiled-coil rod and the nonhelical tailpiece)

Comparator

Wild type or endogenous myosin heavy chain

Outcome

Embryonic contractions, viability, protein localization, and thick filament organization

The rod and tailpiece domains of the myosin heavy chain are required for distinct steps during muscle development in C. elegans.

Hoppe et al. (2003) studied this question.

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Distinguishes essential myosin domains for embryonic muscle function; extends developmental insights but leaves open mammalian cardiac translation.