Functional analysis of a cardiac myosin rod in Dictyostelium discoideum

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Population

Dictyostelium discoideum (wild-type and mhc null cells)

Design

Preclinical

Authors

Discussion

Hypothesis-generating in Dictyostelium; leaves open whether sarcomeric and cytoplasmic myosin rods are interchangeable in mammalian cardiomyocytes.

Population

Dictyostelium discoideum (wild-type and mhc null cells)

Intervention

Transfection with a chimeric gene encoding the Dd myosin head and subfragment 2 fused to rat beta cardiac light meromyosin (LMM)

Outcome

Subcellular localization, growth in suspension, development completion, receptor capping, and actin associationsurrogate

Sarcomeric and cytoplasmic myosin rods appear functionally interchangeable in several aspects of nonmuscle motility in a Dictyostelium model.

LeBlanc-Straceski et al. (1994) studied this question.

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Hypothesis-generating in Dictyostelium; leaves open whether sarcomeric and cytoplasmic myosin rods are interchangeable in mammalian cardiomyocytes.