May 1, 1997European Journal of Clinical Investigation
Neutrophil superoxide release and interleukin 8 in acute myocardial infarction: distinction between complicated and uncomplicated states
Why the study?
Are neutrophil superoxide release and IL-8 levels elevated in complicated versus uncomplicated acute myocardial infarction?
Population
30 patients with acute myocardial infarction and healthy control subjects
Design
Cohort
Authors
Discussion
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Member takes
Implication
Elevated superoxide and IL-8 associate with complicated MI; hypothesis-generating without supporting practice change.
Structured PICO
Are neutrophil superoxide release and IL-8 levels elevated in complicated versus uncomplicated acute myocardial infarction?
P
Population
30 patients with acute myocardial infarction (15 with complicated MI, 15 with uncomplicated MI) and healthy control subjects
C
Comparator
Healthy control subjects; uncomplicated MI patients
O
Outcome
Superoxide release in neutrophils and sera levels of interleukin 8 (IL-8)surrogate
Neutrophil priming and elevated IL-8 levels are associated with complicated acute myocardial infarction, suggesting a role in neutrophil-mediated tissue injury.
Cite This Study
Riesenberg et al. (1997) studied this question.