Key result
NOS3 GG genotype linked to ~4 bpm lower resting HR versus TT in adolescent football players.
Why the study?
NOS3 gene polymorphisms affect nitric oxide synthesis and hemodynamic adaptation, but their relationship with cardiovascular adaptation indicators in adolescent football players required evaluation.
Does the NOS3 G894T gene polymorphism affect cardiovascular adaptation in adolescent football players?
Cross-Sectional (n=160)
Does the NOS3 G894T gene polymorphism affect cardiovascular adaptation in adolescent football players?
Absolute Event Rate: 61.2% vs 65.4%
p-value: p=0.01
The NOS3 G894T GG genotype is associated with a more favorable cardiovascular adaptation profile to physical exertion, including optimal myocardial remodeling and diastolic function, in adolescent football players.
May link NOS3 G894T to CV adaptation in athletes; leaves open clinical relevance pending validation.
In recent years, among the genes associated with success in sports and adaptation to physical exertion, NOS3 (endothelial nitric oxide synthase gene) has garnered particular attention. Polymorphisms of the NOS3 gene affect nitric oxide synthesis, which in turn determines the state of endothelial function, vascular dilation, and hemodynamic adaptation processes. Objective. To evaluate the relationship between cardiovascular system adaptation indicators and NOS3 G894T (Glu298Asp, rs1799983) gene polymorphisms in adolescent football players. Research materials. The study included 100 adolescent football players who train regularly (AF group) and 60 adolescents who participate in sports as part of their school's physical education curriculum (SC group). Conclusion. In the study of the NOS3-G894T (rs1799983) polymorphism, the most favorable adaptation profile was observed in carriers of the GG genotype. They exhibited a lower resting heart rate, a higher incidence of physiological bradycardia, better parameters of autonomic heart rhythm regulation, more pronounced physiological myocardial remodeling, and optimal diastolic function values. Conversely, the presence of the T allele was associated with a decrease in the functional reserves of the cardiovascular system, a reduction in vagal nerve influence, and a shift in the autonomic balance towards sympathetic activity.
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A.A. Ruzieva (2026) conducted a cross-sectional in Cardiovascular adaptation to physical exertion (n=160). NOS3 G894T (rs1799983) GG genotype vs. NOS3 G894T TT/GT genotypes was evaluated on Resting heart rate (bpm) in adolescent football players (p=0.01). The NOS3 GG genotype in adolescent football players was associated with a more favorable cardiovascular adaptation profile, including a significantly lower resting heart rate compared to the TT genotype (61.2 vs 65.4 bpm).
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