What does this research mean for the field?

Physical exercise serves as a pleiotropic therapeutic intervention for metabolic syndrome by restoring metabolic homeostasis through the coordinated modulation of intracellular signaling pathways and myokine-mediated inter-organ communication. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the molecular mechanisms, cellular signaling networks, and organ crosstalk through which physical exercise acts as a therapeutic intervention in metabolic syndrome.

August 23, 2026Current Issues in Molecular BiologyOpen Access

Exercise as a Molecular Therapeutic Strategy in Metabolic Syndrome: Integrating Cellular Signaling, Organ Crosstalk, and Clinical Translation—A Narrative Review

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Authors

HFHéctor Fuentes-BarríaArturo Prat University RARaúl Aguilera-EguíaUniversitat Autònoma de Barcelona MAMiguel Alarcón-RiveraUniversidad Bernardo O'Higgins

Discussion

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Implication

Narrative review demonstrates how exercise restores cellular signaling and organ crosstalk in metabolic syndrome, highlighting its role in precision medicine.

Key Points

To review the molecular mechanisms, cellular signaling networks, and organ crosstalk through which physical exercise acts as a therapeutic intervention in metabolic syndrome.
Synthesized molecular and physiological evidence regarding metabolic dysregulation across skeletal muscle, liver, adipose tissue, and vascular endothelium.
Examined intracellular signaling cascades, myokine secretion profiles, and modality-specific adaptations spanning aerobic, resistance, and high-intensity interval training.
Exercise activates AMPK, PGC-1α-driven mitochondrial biogenesis, and Nrf2 antioxidant responses, boosting glucose uptake and fatty acid oxidation while diminishing ectopic lipid accumulation.
Contracting skeletal muscle secretes regulatory myokines, including irisin, IL-6, and FGF21, which mediate multi-organ communication, reduce pro-inflammatory cytokines, and improve endothelial function.
Different training modalities stimulate shared and distinct molecular targets, supporting precision exercise prescriptions for cardiometabolic disease.

Cite This Study

Fuentes-Barría et al. (2026) studied this question.

synapsesocial.com/papers/6a8aae0f7677a34114446d02 https://doi.org/10.3390/cimb48080850

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Implication

Narrative review demonstrates how exercise restores cellular signaling and organ crosstalk in metabolic syndrome, highlighting its role in precision medicine.

Exercise as a Molecular Therapeutic Strategy in Metabolic Syndrome: Integrating Cellular Signaling, Organ Crosstalk, and Clinical Translation—A Narrative Review

Discussion

Member takes

Implication

Key Points

Cite This Study

Exercise as a Molecular Therapeutic Strategy in Metabolic Syndrome: Integrating Cellular Signaling, Organ Crosstalk, and Clinical Translation—A Narrative Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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