November 1, 2003Journal of Cardiovascular Electrophysiology
Combined Efficacy of Atrial Septal Lead Placement and Atrial Pacing Algorithms for Prevention of Paroxysmal Atrial Tachyarrhythmia
Why the study?
Do atrial prevention pacing algorithms reduce AT/AF frequency or burden in patients with bradycardia and paroxysmal AT/AF implanted with a DDDRP pacing system?
Population
298 patients with bradycardia and paroxysmal atrial tachyarrhythmia implanted with a DDDRP pacing system…
Comparison
Atrial prevention pacing algorithms ON for 3… vs Atrial prevention pacing algorithms OFF for 3…
Design
RCT, Lead site was randomized at implant to right atrial septal or nonseptal…
Follow-up
6 months (two 3-month cross-over periods)
Authors
Discussion
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Overview
Prevention pacing algorithms do not reduce device-recorded AT/AF burden; confirms lack of efficacy and challenges routine activation in bradycardia patients with paroxysmal AF.
Structured PICO
Do atrial prevention pacing algorithms reduce AT/AF frequency or burden in patients with bradycardia and paroxysmal AT/AF implanted with a DDDRP pacing system?
P
Population
298 patients with bradycardia and paroxysmal atrial tachyarrhythmia (AT/AF) implanted with a DDDRP pacing system, mean age 70 +/- 10 years, 61% male, from 35 centers.
I
Intervention
Atrial prevention pacing algorithms ON for 3 months
C
Comparator
Atrial prevention pacing algorithms OFF for 3 months
O
Outcome
Device-recorded AT/AF frequency or burdensurrogate
Atrial prevention pacing algorithms do not reduce device-recorded AT/AF burden, though they may reduce premature atrial contractions and symptomatic episodes in patients with septal leads.
Cite This Study
Padeletti et al. (2003) studied this question.