Why the study?
Does switching from simvastatin to pravastatin improve the obstructive apnoea index in a patient experiencing sleep apnoea on simvastatin?
Does switching from simvastatin to pravastatin improve the obstructive apnoea index in a patient experiencing sleep apnoea on simvastatin?
Switching from simvastatin to pravastatin may resolve statin-induced sleep apnoea.
Answers are grounded in this paper and cite their sources.
May suggest reversible statin-associated sleep apnoea; hypothesis-generating case observation requiring controlled confirmation.
Sleep problems have been reported as an adverse effect of statins. In a randomised trial, simvastatin at 20 mg produced significantly worse sleep quality than either placebo or pravastatin 40 mg. A possible relation to sleep apnoea was hypothesised. Here, the case of a 67-year-old man who experienced sleep apnoea on simvastatin 20 mg is presented. Objective nightly testing showed a prompt, marked, sustained and statistically significant improvement in the obstructive apnoea index when the patient switched to pravastatin 20 mg.
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Cham et al. (2009) studied this question.
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