Why the study?
Does 60° head-up tilt alter renal sodium handling via renal sympathetic nerves in anesthetized dogs?
Population
Anaesthetized dogs
Comparison
10 min of 60 degrees head-up tilt under various… vs Intact animals vs denervated/blocked animals…
Design
Preclinical
Follow-up
10 minutes
Authors
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Should not change clinical practice; hypothesis-generating for baroreflex–sympathetic control of renal sodium handling.
Does 60° head-up tilt alter renal sodium handling via renal sympathetic nerves in anesthetized dogs?
The decrease in renal sodium excretion during a 60° head-up tilt in anesthetized dogs is mediated by renal sympathetic nerves acting via alpha-adrenergic receptors, activated by the carotid sinus baroreceptor reflex.
DiBona et al. (1980) studied this question.
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