Key result
During head up tilt, spontaneously hypertensive rats exhibited a greater fall in blood pressure and stroke volume compared to normotensive control rats, with the reverse true for head down tilt.
Why the study?
Do haemodynamic shifts during head up and head down tilt differ between spontaneously hypertensive rats and normotensive control rats under autonomic blockade?
Population
Adult spontaneously hypertensive rats (SHR) and matched normotensive control rats (NCR)
Comparison
Head up and head down tilt under nembutal… vs Normotensive control rats (NCR)
Design
Preclinical
Authors
Loading...
May indicate altered Frank-Starling response in hypertrophied hearts; leaves open translation to human hypertension.
Do haemodynamic shifts during head up and head down tilt differ between spontaneously hypertensive rats and normotensive control rats under autonomic blockade?
Spontaneously hypertensive rats exhibit an altered cardiac response to venous filling, suggesting an altered Frank-Starling relationship in the hypertrophied heart.
Noresson et al. (1977) studied Hypertension. Head up and head down tilt vs. Normotensive control rats (NCR) was evaluated on Haemodynamic shifts (blood pressure and stroke volume). During head up tilt, spontaneously hypertensive rats exhibited a greater fall in blood pressure and stroke volume compared to normotensive control rats, with the reverse true for head down tilt.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: