March 16, 2005Journal of Cardiovascular Pharmacology

Experimental Orthostasis Elicits Sustained Hypertension, Which Can Be Prevented by Sympathetic Blockade in the Rat

View Full Paper

Ask AI

Bookmark

Population

Normotensive and hypertensive Wistar rats (hypertension induced by blockade of nitric oxide synthesis)

Comparison

45 degrees head-up tilt, with or without… vs Horizontal control

Design

Preclinical

Authors

GRGábor RaffaiSemmelweis University MMMárta Mészáros MKMárk KollaiSemmelweis University

Discussion

Member takes

Implication

Hypothesis-generating rat model of orthostatic hypertension; leaves open translation to human sympathetic blockade.

Structured PICO

Population

Normotensive and hypertensive Wistar rats (hypertension induced by blockade of nitric oxide synthesis)

Intervention

45 degrees head-up tilt (repeated 3 times for 5 minutes, or sustained for 120 minutes), with or without prazosin (10 mg/kgbw) or chloralose (26 mg/kgbw)

Comparator

Horizontal control

Outcome

Arterial blood pressure and heart ratesurrogate

Conscious rats respond to sustained orthostasis with hypertension, likely due to increased sympathetic output, providing a potential model for studying orthostatic hypertension.

Cite This Study

Raffai et al. (2005) studied this question.

synapsesocial.com/papers/6a6fc202febe604dd7089bec https://doi.org/10.1097/01.fjc.0000157440.57236.58

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Experimental Orthostasis Elicits Sustained Hypertension, Which Can Be Prevented by Sympathetic Blockade in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Experimental Orthostasis Elicits Sustained Hypertension, Which Can Be Prevented by Sympathetic Blockade in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider