Population
Cardiac myofibrils from cardiomyopathic hamsters, control hamsters, and dog hearts
Comparison
Incubation with isolated troponin-tropomyosin… vs Myofibrils from control hamsters
Design
Preclinical
Authors
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Abnormal troponin-tropomyosin regulation may underlie contractile impairment in cardiomyopathy; leaves open human therapeutic relevance.
In a hamster model of cardiomyopathy, abnormalities in the troponin-tropomyosin complex contribute to altered myofibrillar ATPase activity and decreased calcium stimulation.
Malhotra et al. (1990) studied this question.
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