Key result
Angiotensin II induces renal tubular epithelial cell hypertrophy through HB-EGF shedding-dependent EGFR transactivation and activation of TGF-beta signaling pathways.
This study demonstrates that Angiotensin II induces renal tubular epithelial cell hypertrophy through a mechanism involving HB-EGF shedding-dependent EGFR transactivation and TGF-beta signaling.
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May inform future target validation in hypertensive nephropathy; hypothesis-generating in animal models only and should not change practice.
Chen et al. (2006) studied Renal epithelial cell hypertrophy. Angiotensin II vs. Empty vector-transfected cells or specific inhibitors was evaluated on EGFR transactivation and cellular hypertrophy. Angiotensin II induces renal tubular epithelial cell hypertrophy through HB-EGF shedding-dependent EGFR transactivation and activation of TGF-beta signaling pathways.
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