Key result
Terfenadine decreased the maximum rate of rise in Purkinje fibers and atrium but did not prolong action potential duration in rabbit myocardial tissue preparations.
Why the study?
Does terfenadine prolong action potential duration in isolated rabbit myocardial tissue preparations?
Population
Male Japanese white rabbits weighing 2.0 to 2.5 kg and HEK293 cells expressing human ether a go-go-related…
Comparison
Terfenadine applied to the tissue bath or… vs Baseline or absence of drug.
Design
Preclinical
Authors
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Isolated rabbit tissue APD assays may miss proarrhythmic risk of HERG blockers like terfenadine; leaves open questions on assay reliability for preclinical screening.
Does terfenadine prolong action potential duration in isolated rabbit myocardial tissue preparations?
The lack of action potential prolongation by terfenadine in isolated tissue, despite its known HERG inhibition and in vivo QT prolongation, suggests that isolated tissue APD assays may not reliably predict the arrhythmogenic risk of all drugs.
Masumiya et al. (2004) studied this question. Terfenadine vs. Baseline was evaluated on Action potential duration (APD) and maximum rate of rise (Vmax). Terfenadine decreased the maximum rate of rise in Purkinje fibers and atrium but did not prolong action potential duration in rabbit myocardial tissue preparations.
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