August 1, 1997Circulation Research

Inhibition of L-Type Ca²⁺Channel Current in Rat Ventricular Myocytes by Terfenadine

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Population

Adult rat ventricular myocytes

Design

Preclinical

Authors

SLShi LiuJishou University RMRussell B. MelchertUniversity of Missouri–Kansas City RKRichard H. KennedyDeakin University

Discussion

Member takes

Implication

May contribute to terfenadine cardiotoxicity; leaves open relevance to human myocytes at therapeutic concentrations.

Structured PICO

Population

Adult rat ventricular myocytes

Intervention

Terfenadine (10(-9) to 5 x 10(-6) mol/L)

Outcome

Inhibition of L-type Ca2+ channel current (ICa,L)surrogate

Terfenadine inhibits L-type Ca2+ channels in adult rat ventricular myocytes predominantly by interacting with the inactivated state, providing a potential mechanism for its cardiotoxicity.

Cite This Study

Liu et al. (1997) studied this question.

synapsesocial.com/papers/6a7f0ba0088720e7049b2c0d https://doi.org/10.1161/01.res.81.2.202

View Full Paper

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Inhibition of L-Type Ca²⁺Channel Current in Rat Ventricular Myocytes by Terfenadine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of L-Type Ca²⁺Channel Current in Rat Ventricular Myocytes by Terfenadine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider