Why the study?
Does KW-4679 or terfenadine prolong action potential duration in isolated guinea pig ventricular myocytes?
Population
Isolated guinea pig ventricular myocytes
Design
Preclinical
Authors
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May support lower proarrhythmic risk for KW-4679; leaves open clinical translation in humans.
Does KW-4679 or terfenadine prolong action potential duration in isolated guinea pig ventricular myocytes?
Unlike terfenadine, the novel antiallergic compound KW-4679 does not prolong action potential duration in preclinical models, suggesting a lower proarrhythmic risk.
Kato et al. (1996) studied this question.
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