Population
Monkeys and rats (preclinical models)
Design
Preclinical
Authors
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IV efficacy in monkeys supports preclinical optimization; leaves open oral viability due to rat hepatic extraction.
A newly designed water-soluble renin inhibitor showed potent intravenous efficacy but limited oral bioavailability due to high hepatic extraction.
Rosenberg et al. (1990) studied this question.
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