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February 18, 2013Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Renoprotective effects of the direct renin inhibitor aliskiren on gentamicin-induced nephrotoxicity in rats

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Key result

Aliskiren attenuated gentamicin-induced nephropathy in rats and HK-2 cells by suppressing inflammatory, profibrotic, and apoptotic factors.

Why the study?

Does aliskiren prevent gentamicin-induced nephrotoxicity in rats and human proximal tubular epithelial cells?

Population

Rats injected with gentamicin for 14 days, and human proximal tubular epithelial cell lines cultured with…

Comparison

Aliskiren infused for two weeks and co-cultured. vs Gentamicin treatment alone without aliskiren.

Design

Preclinical

Follow-up

14 days

Authors

EBEun Hui BaeIKIn Jin KimSJSoo Yeon Joo

Discussion

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Overview

Preclinical findings warrant no clinical change; leaves open whether aliskiren prevents gentamicin nephrotoxicity in humans.

Structured PICO

Does aliskiren prevent gentamicin-induced nephrotoxicity in rats and human proximal tubular epithelial cells?

P
Population
Rats and human proximal tubular epithelial cell lines (HK-2) treated with gentamicin to induce nephropathy.
I
Intervention
Aliskiren infused for two weeks (in vivo) and co-cultured (in vitro).
C
Comparator
Gentamicin treatment alone without aliskiren.
O
Outcome
Renal function (creatinine clearance, fractional sodium excretion), histological changes (glomerulosclerosis, tubulointerstitial fibrosis), and inflammatory, profibrotic, and apoptotic markers.surrogate

Aliskiren demonstrates renoprotective effects against gentamicin-induced nephrotoxicity in preclinical models by suppressing inflammatory, profibrotic, and apoptotic pathways.

Cite This Study

Bae et al. (2013) studied Gentamicin-induced nephropathy. Aliskiren vs. Gentamicin alone was evaluated on Inflammatory, profibrotic, and apoptotic markers, creatinine clearance, and fibrosis. Aliskiren attenuated gentamicin-induced nephropathy in rats and HK-2 cells by suppressing inflammatory, profibrotic, and apoptotic factors.

synapsesocial.com/papers/6a8acba4de5ec4e001e3a322https://doi.org/10.1177/1470320312474853
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Also Consider

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