What question did this study set out to answer?

To evaluate the clinical efficacy, pharmacokinetics, antimicrobial sensitivity, and toxicity of parenteral aminoglycosides in surgical ward patients experiencing serious bacterial sepsis.

June 1, 1976Annals of SurgeryOpen Access

Use of Aminoglycosides in Surgical Infections

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Authors

HSH. Harlan StoneUniversity of Maryland, Baltimore LKLAURA D. KOLBJohannes Gutenberg University Mainz CGCAROL E. GEHEBEREmory University

Discussion

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Implication

Prospective study reveals robust efficacy and renal toxicity risks of aminoglycosides in surgical patients, highlighting the need for dosage adjustments based on serum creatinine.

Key Points

To evaluate the clinical efficacy, pharmacokinetics, antimicrobial sensitivity, and toxicity of parenteral aminoglycosides in surgical ward patients experiencing serious bacterial sepsis.
Prospectively evaluated 405 surgical patients receiving aminoglycoside therapy (gentamicin, tobramycin, sisomicin, or amikacin) over a 40-month observation period.
Assessed indications, serum drug concentrations across administration routes, urinary excretion rates, in vitro bacterial sensitivities via disc and tube dilution, and renal function via serum creatinine.
Intravenous administration promoted more rapid achievement of therapeutic serum antibiotic concentrations than alternative administration routes.
Aminoglycosides demonstrated superior therapeutic efficacy against established abdominal and surgical infections, though drug toxicity increased notably in dehydrated and shocked patients.
Safe and successful outcomes depended heavily on modifying drug doses via frequent serum creatinine monitoring, early surgical debridement and drainage, and active prevention of secondary Candida sepsis.

Cite This Study

Stone et al. (1976) studied this question.

synapsesocial.com/papers/6a8acc1c1692ae2bc0f446de https://doi.org/10.1097/00000658-197606000-00007

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Implication

Prospective study reveals robust efficacy and renal toxicity risks of aminoglycosides in surgical patients, highlighting the need for dosage adjustments based on serum creatinine.

Use of Aminoglycosides in Surgical Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

Use of Aminoglycosides in Surgical Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

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