Why the study?
Does FK453 improve renal function in rats with glycerol-induced acute renal failure?
Does FK453 improve renal function in rats with glycerol-induced acute renal failure?
FK453, a nonxanthine adenosine A1 receptor antagonist, ameliorates glycerol-induced acute renal failure in rats, suggesting adenosine A1 receptor mediation in this ARF model.
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Animal data support A1 antagonism in experimental ARF; leaves open translation to clinical acute kidney injury.
Terai et al. (1996) studied this question.
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