December 1, 1961British Journal of Pharmacology and ChemotherapyOpen Access

Effect of Morphine on Some Sympathetically Innervated Effectors

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Why the study?

Does morphine inhibit sympathetically innervated effectors in cats?

Population

Cats (nictitating membrane, cardiac nerves, splenic nerves)

Design

Preclinical

Authors

ACA. B. CairnieArgonne National Laboratory HKH. W. KosterlitzUniversity of Aberdeen DTD. Wayne TaylorCross-Cutting Cardiology

Discussion

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Implication

Suggests selective sympathetic modulation by morphine in feline models; leaves open translational relevance to human cardiovascular pharmacology.

Structured PICO

Does morphine inhibit sympathetically innervated effectors in cats?

Population

Cats (nictitating membrane, cardiac nerves, splenic nerves)

Intervention

Morphine (0.5 to 55 mg/kg)

Outcome

Contraction of the nictitating membrane following stimulation of postganglionic sympathetic nerve fibressurrogate

Morphine inhibits sympathetically mediated contraction of the nictitating membrane in cats, likely by reducing noradrenaline release from postganglionic nerve endings.

Cite This Study

Cairnie et al. (1961) studied this question.

synapsesocial.com/papers/6a8ada20c12eaf65c8b1e9ea https://doi.org/10.1111/j.1476-5381.1961.tb01141.x

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Implication

Suggests selective sympathetic modulation by morphine in feline models; leaves open translational relevance to human cardiovascular pharmacology.

Effect of Morphine on Some Sympathetically Innervated Effectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Morphine on Some Sympathetically Innervated Effectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider