Why the study?
Are commercial PTT methods as sensitive as standardized PTT methods in measuring the anticoagulant effect of heparin?
Population
Over 300 hospitals in the U.S. and overseas evaluating PTT methods for heparin measurement
Comparison
Commercial PTT methods and non-commercial… vs Standardized PTT method
Design
Cross-sectional
Authors
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Commercial PTT methods may underestimate heparin effect; leaves open need for standardized calibration in routine monitoring.
Are commercial PTT methods as sensitive as standardized PTT methods in measuring the anticoagulant effect of heparin?
Commercial PTT methods are relatively insensitive to heparin compared to standardized methods, demonstrating the value of a sensitive reference preparation for calibration.
Poller et al. (1980) studied this question.
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