Why the study?
Does propranolol suppress recurrent ventricular fibrillation in patients with normal QT intervals?
Does propranolol suppress recurrent ventricular fibrillation in patients with normal QT intervals?
Propranolol may be effective in suppressing recurrent ventricular fibrillation in patients with normal QT intervals, suggesting a possible forme fruste of long QT syndrome.
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Propranolol may suppress recurrent VF with normal QT; hypothesis-generating for forme fruste long QT syndrome.
Two patients after being treated for epilepsy for 20 years were found to have recurrent syncope due to ventricular fibrillation. Neither had structural heart disease. The first patient had normal QT and QTc values at all times, and the second had a normal QT interval and an intermittently abnormal U wave. In both patients, attacks were suppressed totally by propranolol. These cases, and some similar patients reported previously suggest that there may be a forme fruste of the long QT syndrome.
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T.R.D. Shaw (1981) studied this question.
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