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May 19, 2022Frontiers in EndocrinologyOpen Access

High Prevalence of Cardiometabolic Comorbidities Among Children and Adolescents With Severe Obesity From a Large Metropolitan Centre (Hangzhou, China)

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Key result

Among Chinese children and adolescents with severe obesity, there was a high prevalence of cardiometabolic comorbidities, with the incidence of several conditions such as hypertension and type 2 diabetes rising markedly between 2008-2012 and 2013-2017.

Why the study?

The study was designed to describe the clinical characteristics of children and adolescents with obesity and the 10-year prevalence of cardiometabolic comorbidities in this population from a large metropolitan centre in China.

Population

2,916 children and adolescents aged <18 years with obesity in Hangzhou, China

Comparison

Stratified by sex, age bands (<10 vs ≥10 years), and time period (2008-2012 vs 2013-2017)

Design

Cross-sectional study

Authors

JWJinling WangNanjing Forestry UniversityLHLin HuCentral Hospital of ZiboVCValentina ChiavaroliOspedale di Santo Spirito

Discussion

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Implication

May warrant intensified screening in obese Chinese youth; leaves open longitudinal studies to guide prevention.

Study Design

Type

Cross-Sectional (n=2,916)

Multicenter

No

Structured PICO

P
Population
2,916 children and adolescents aged <18 years with severe obesity from a single center in China, assessed for cardiometabolic comorbidities over a 10-year period.
O
Outcome
Prevalence of obesity-related cardiometabolic comorbidities (including type 2 diabetes, abnormal glycaemia, hypertension, dyslipidaemia, hyperuricaemia, acanthosis nigricans, abnormal liver function, NAFLD, and metabolic syndrome) and their trends over a 10-year period (2008-2017).

There is a high and rapidly increasing prevalence of cardiometabolic comorbidities, particularly hypertension and abnormal glycaemia, among Chinese children and adolescents with severe obesity.

Limitations

  • Lack of complete data on pubertal development
  • Study population skewed towards the upper end of the BMI SDS spectrum (severe obesity), limiting generalizability to moderate obesity
  • Potential regional bias as patients were assessed in east China
  • Cross-sectional design precludes ascertaining the progression of obesity-related comorbidities in individual patients over time
  • Lack of data on dietary habits and physical activity levels
  • Lack of data on the clinical history of patients, particularly regarding weight gain over time

Cite This Study

Wang et al. (2022) conducted a cross-sectional in Severe obesity (n=2,916). Time period (2013-2017) vs. Time period (2008-2012) was evaluated on Prevalence of obesity-related cardiometabolic comorbidities. Among Chinese children and adolescents with severe obesity, there was a high prevalence of cardiometabolic comorbidities, with the incidence of several conditions such as hypertension and type 2 diabetes rising markedly between 2008-2012 and 2013-2017.

synapsesocial.com/papers/6a8adae7d5d4290f64f44dfahttps://doi.org/10.3389/fendo.2022.807380

Topics

Hypertension management
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Also Consider

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  1. 1Pediatric Hypertension2020 · 3 citations
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  3. 3Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Children and Adolescents With Obesity2020 · 51 citations
  4. 4Hypertension in childhood obesity2018 · 133 citations
  5. 5Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association2018 · 352 citations