What question did this study set out to answer?

To evaluate surgical and oncologic outcomes and determine prognostic factors in patients presenting with extensive stage T4 squamous cell carcinoma of the vocal cords.

September 1, 1975The Laryngoscope

Panel discussion on glottic tumors. I. The evaluation of treatment of patients with extensive squamous cancer of the vocal cords

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Authors

RJRichard H. JesseUnited States Army Medical Command

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Implication

Cohort study reveals a 54 percent disease-free survival after total laryngectomy in stage T4 glottic cancer, highlighting the need for postoperative radiation in high-risk patients.

Key Points

To evaluate surgical and oncologic outcomes and determine prognostic factors in patients presenting with extensive stage T4 squamous cell carcinoma of the vocal cords.
Analyzed 51 patients (N=48 treated; median age 66 years) with previously untreated stage T4 vocal cord squamous carcinoma undergoing at least total laryngectomy.
Administered postoperative radiation therapy to 16 patients based on clinical and pathologic risk features.
Evaluated pathological spread, clinical nodal staging accuracy, prior emergency airway procedures, and causes of mortality over four years of follow-up.
Extralaryngeal spread was pathologically confirmed in 98% (47/48) of surgical patients, and clinical nodal examination showed a 20% false-negative rate.
Disease-free status was maintained in 54% (26/48) of treated patients, while 27% died of non-cancer causes within four years.
Treatment failure and reduced survival were significantly associated with prior emergency tracheostomy (present in 21% before referral), pharyngeal wall extension, and positive cervical lymph nodes, whereas isolated tracheal extension was not an adverse factor.

Cite This Study

Richard H. Jesse (1975) studied this question.

synapsesocial.com/papers/6a8ade1d5ef9ff12d7892d12 https://doi.org/10.1288/00005537-197509000-00002

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Implication

Cohort study reveals a 54 percent disease-free survival after total laryngectomy in stage T4 glottic cancer, highlighting the need for postoperative radiation in high-risk patients.

Panel discussion on glottic tumors. I. The evaluation of treatment of patients with extensive squamous cancer of the vocal cords

Discussion

Member takes

Implication

Key Points

Cite This Study

Panel discussion on glottic tumors. I. The evaluation of treatment of patients with extensive squamous cancer of the vocal cords

Discussion

Member takes

Implication

Key Points

Cite This Study

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