Phenylheptatriyne (PHT) does not kill bacteriophage T4B0 r during irradiation with light of 360 nm whereas 8-methoxypsoralen (8-MOP) does. Murine cytomegalovirus (MCMV), a membrane-coated DNA virus, and PM2, a lipid-containing bacteriophage, are inactivated by irradiation in the presence of PHT. The primary phototoxic effect of PHT appears to be exerted on membranes rather than on DNA [2], whereas that of 8-MOP is exerted at the level of DNA [13,14]. Since T4B0 r and PM2 can be irradiated as a mixed suspension, these bacteriophages afford a useful system for the preliminary analysis of the mechanism of action of a given phototoxic compound.
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Warren et al. (1980) studied this question.
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