Why the study?
Does 5-(N,N-dimethyl)amiloride (DMA) protect against ischemia-reperfusion injury in isolated rat hearts?
Population
Coronary perfused isolated rat right ventricular wall
Comparison
5-amiloride at 1, 5, or 20 microM in the perfusate vs DMA-untreated hearts
Design
Preclinical
Follow-up
60 min of ischemia followed by 30 min of reperfusion
Authors
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DMA attenuates postischemic dysfunction in rat hearts; leaves open whether Na+/H+ exchange inhibition protects human myocardium from ischemia-reperfusion injury.
Does 5-(N,N-dimethyl)amiloride (DMA) protect against ischemia-reperfusion injury in isolated rat hearts?
DMA significantly protects the isolated rat heart during the initial stages of reperfusion, suggesting Na(+)-H+ exchange plays a key role in ischemia-reperfusion injury.
Meng et al. (1990) studied this question.
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