Why the study?
Does dimethyl amiloride improve myocardial contractile function in isolated rat hearts following hemorrhagic shock?
Population
Sprague-Dawley rats subjected to 1 h of hemorrhagic shock or sham hemorrhage (n=24 total, 6 per group)
Comparison
20 microM dimethyl amiloride added for the first… vs Hemorrhage without DMA, sham hemorrhage + DMA…
Design
Preclinical
Follow-up
60 min
Authors
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Hypothesis-generating for NHE inhibition after hemorrhagic shock; requires in vivo and clinical validation before any practice consideration.
Does dimethyl amiloride improve myocardial contractile function in isolated rat hearts following hemorrhagic shock?
In a rat model of hemorrhagic shock, blocking the cardiac Na+-H+ exchanger with dimethyl amiloride during ex vivo perfusion protected myocardial contractile function.
Mona Soliman (2009) studied this question.
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