What is the clinical evidence from this study?

Study design: RCT. Population: Hypertension-induced renal damage. Intervention: Captopril vs. vehicle. Primary outcome: blood pressure, renal injury, renal inflammation, and NF-κB activation.

January 1, 2018Brazilian Journal of Medical and Biological ResearchOpen Access

Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

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Key result

Long-term captopril treatment lowered blood pressure, improved renal injury, and suppressed renal inflammation and NF-κB activation in spontaneously hypertensive rats.

Why the study?

Does captopril reduce hypertension-induced renal damage and inflammation in spontaneously hypertensive rats?

Population

6-week-old male spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats

Comparison

Captopril 34 mg/kg (long-term treatment) vs Vehicle

Design

Preclinical, randomized

Follow-up

long-term

Authors

ZGZhongyuan GanShanghai University of Traditional Chinese Medicine DHDan HuangNanjing University of Chinese Medicine JJJiaye JiangShanghai University of Traditional Chinese Medicine

Discussion

Member takes

Implication

Cautions against clinical extrapolation; leaves open NF-κB as a therapeutic target in hypertensive nephropathy.

Study Design

Type

RCT

Randomization

randomized

Structured PICO

Does captopril reduce hypertension-induced renal damage and inflammation in spontaneously hypertensive rats?

Population

6-week-old male spontaneously hypertensive rats and age-matched Wistar-Kyoto rats randomized to long-term captopril or vehicle.

Intervention

Captopril 34 mg/kg (long-term treatment)

Comparator

Vehicle

Outcome

Renal injury (urine albumin, total protein, serum creatinine, blood urea nitrogen), renal inflammation (TNF-α, IL-1β, IL-6, iNOS), and NF-κB activationsurrogate

Captopril ameliorates hypertension-induced renal injury and inflammation in a rat model, potentially via NF-κB signaling inactivation.

Cite This Study

Gan et al. (2018) conducted an RCT in Hypertension-induced renal damage. Captopril vs. vehicle was evaluated on blood pressure, renal injury, renal inflammation, and NF-κB activation. Long-term captopril treatment lowered blood pressure, improved renal injury, and suppressed renal inflammation and NF-κB activation in spontaneously hypertensive rats.

synapsesocial.com/papers/6a8ae623f71b672e3df4540c https://doi.org/10.1590/1414-431x20187338

Topics

Hypertension management

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Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Topics

Captopril alleviates hypertension-induced renal damage, inflammation, and NF-κB activation

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider