Key result
The Hypotension Prediction Index software will be evaluated in a randomized controlled trial to determine if it reduces the duration and severity of intraoperative hypotension during non-cardiac surgery.
Why the study?
Hypotension is associated with myocardial infarction, acute kidney injury, and mortality, and predicting and preventing it may improve outcomes.
Population
213 noncardiac surgical patients > 45 years old requiring intra-arterial blood pressure monitoring
Comparison
Unblinded HPI software guidance vs blinded HPI monitoring
Design
Two-center pragmatic randomized controlled trial
Authors
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RCT (n=213)
Double-blind (patients and data analysts blinded; clinicians unblinded)
Stratified by study site, with randomly sized blocks achieving a 1:1 balance within site
Yes
Maheshwari et al. (2019) conducted an RCT in Moderate- to high-risk noncardiac surgery (n=213). Hypotension Prediction Index (HPI) software guidance vs. Blinded HPI software (routine invasive arterial pressure monitoring) was evaluated on Intraoperative time-weighted average (TWA) mean arterial pressure (MAP) under a threshold of 65 mmHg. The Hypotension Prediction Index software will be evaluated in a randomized controlled trial to determine if it reduces the duration and severity of intraoperative hypotension during non-cardiac surgery.
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