Key result
Early appendectomy significantly reduced time away from normal activities compared with interval appendectomy (13.8 vs 19.4 days; P<0.001) and lowered overall adverse events (30% vs 55%; P=0.003).
Why the study?
Does early appendectomy reduce time away from normal activities in children with perforated appendicitis compared to interval appendectomy?
Population
131 patients younger than 18 years with a preoperative diagnosis of perforated appendicitis
Comparison
Early appendectomy (within 24 hours of admission) vs Interval appendectomy (6-8 weeks after diagnosis)
Design
RCT, Randomized, Nonblinded
Authors
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Supports early appendectomy as preferred for pediatric perforated appendicitis; confirms RCT superiority to interval approach for recovery and safety.
RCT (n=131)
Open-label
randomized
No
Does early appendectomy reduce time away from normal activities in children with perforated appendicitis compared to interval appendectomy?
Absolute Event Rate: 13.8% vs 19.4%
p-value: p=< .001
Early appendectomy in children with perforated appendicitis significantly reduces time away from normal activities and adverse events compared to interval appendectomy.
Blakely et al. (2011) conducted an RCT in perforated appendicitis (n=131). Early appendectomy vs. Interval appendectomy (6-8 weeks after diagnosis) was evaluated on Time away from normal activities (days) (p=< .001). Early appendectomy significantly reduced time away from normal activities compared with interval appendectomy (13.8 vs 19.4 days; P<0.001) and lowered overall adverse events (30% vs 55%; P=0.003).
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