Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1999Nephrology Dialysis Transplantation

Functional correlates of α2A-adrenoceptor gene polymorphism in the HANE study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the presence of the d allele of the alpha(2A)-adrenoceptor gene associate with alterations in blood pressure, lipid, and carbohydrate metabolism in hypertensive patients?

Population

147 hypertensive patients

Comparison

Presence of the d allele of the… vs Absence of the d allele of the…

Design

Cross-sectional

Authors

MMMartin C. MichelJohannes Gutenberg University MainzCPChristopher PlogmannUniversity of Duisburg-EssenTPThomas PhilippSemmelweis University

Discussion

Loading...

Member takes

Implication

d allele linked to better glycemic/lipid profiles in hypertension; hypothesis-generating, should not yet change practice.

Structured PICO

Does the presence of the d allele of the alpha(2A)-adrenoceptor gene associate with alterations in blood pressure, lipid, and carbohydrate metabolism in hypertensive patients?

P
Population
147 hypertensive patients
I
Intervention
Presence of the d allele of the alpha(2A)-adrenoceptor gene
C
Comparator
Absence of the d allele of the alpha(2A)-adrenoceptor gene
O
Outcome
Blood pressure, family history of hypertension, and clinical chemistry parameters (including HbA1, HbA1c, total cholesterol, glucose, triglycerides, and LDL cholesterol)surrogate

The alpha(2A)-adrenoceptor gene polymorphism is associated with favorable differences in lipid and glucose metabolism, but not blood pressure, in hypertensive patients.

Cite This Study

Michel et al. (1999) studied this question.

synapsesocial.com/papers/6a8af180c12eaf65c8b1f066https://doi.org/10.1093/ndt/14.11.2657

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet α2-adrenergic receptors in hypercholesterolemia: Relationship between binding studies and epinephrine-induced platelet aggregation1997 · 24 citations
  2. 2Genetic aspects of variability in superficial vein responsiveness to norepinephrine1991 · 37 citations
  3. 3Randomised, double blind, multicentre comparison of hydrochlorothiazide, atenolol, nitrendipine, and enalapril in antihypertensive treatment: results of the HANE study1997 · 169 citations
  4. 4Neuropeptide Y-Related Peptides and their Receptors--Are the Receptors Potential Therapeutic Drug Targets?1993 · 386 citations