Key result
Higher adiponectin receptor expression (AdipoR+) on leukocytes in hypertensive children was associated with more frequent severe ambulatory hypertension compared to AdipoR(-) patients (51.6% vs 26.9%, P<0.01).
Observational (n=76)
In children with primary hypertension, upregulation of neutrophil adiponectin receptors is associated with greater hypertension severity, early vascular injury (increased CIMT), and lower serum adiponectin levels.
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Does not support changing practice in pediatric hypertension; hypothesis-generating for leukocyte AdipoR in ambulatory BP severity.
The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical parameters. The group of 26 patients [AdipoR(-)] showed lower and the group of 31 patients [AdipoR(+)] showed higher AdipoRs protein expression than the control and each other (P < 0.01 for neutrophils, P < 0.05 for monocytes). The AdipoR(+) leukocytes expressed higher AdipoR1 mRNA levels (RT-PCR) than AdipoR(-) ones and controls (P = 0.022 and P = 0.007, resp.). Despite greater BMI, the AdipoR(-) patients had unchanged serum adiponectin levels. In contrast, AdipoR(+) patients had lower serum adiponectin concentrations than the AdipoR(-) ones and controls (P < 0.001). The AdipoR(+) patients had higher blood pressure (P = 0.042) and greater carotid intima-media thickness (P = 0.017) than the AdipoR(-) ones. The stage of hypertension was associated with increased neutrophil but not monocyte AdipoR1 density (AdipoR1 MFI) (P < 0.05). Severe ambulatory hypertension was presented more often in AdipoR(+) patients than in AdipoR(-) ones (51.6% versus 26.9%, resp.; P < 0.01). In conclusion, neutrophil AdipoRs upregulation was associated with early stages of vascular injury, hypertension severity, and low serum levels of adiponectin.
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Gackowska et al. (2015) conducted an observational in Primary hypertension (n=76). Adiponectin receptor (AdipoR) upregulation vs. AdipoR(-) expression and healthy controls was evaluated on Severe ambulatory hypertension (p=<0.01). Higher adiponectin receptor expression (AdipoR+) on leukocytes in hypertensive children was associated with more frequent severe ambulatory hypertension compared to AdipoR(-) patients (51.6% vs 26.9%, P<0.01).
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