The FTO rs9939609, ADIPOQ rs1501299, rs822391, and ADIPOR2 rs16928662 Polymorphisms Relationship to Obesity and Metabolic Syndrome in Bulgarian Sample

The allele frequencies of four SNPs in FTO, ADIPOQ and ADIPOR2 genes were investigated for the first time in a sample of Bulgarian population. The distribution of genotypes for the rs9939609, rs1501299, rs822391 and rs16928662 polymorphisms was in accordance with Hardy-Weinberg equilibrium and correlated with genotype data for other populations A case-control association study among normal control subjects and subjects with adult obesity according to the waist/hip circumferences ratio was performed and relationship to metabolic syndrome was explored. A direct and convincing linkage between obesity or metabolic syndrome risk and the studied SNP genotypes in Bulgarian population has not been established. One reason could be the small sample size. Also environmental impact and metabolic flexibility possibly play greater role in health status than the simplified causative relationship between genotype and obesity and metabolic syndrome related diseases.