Key result
The ADIPOR1 rs2275738 'CC' genotype was associated with a 107% increased risk for biopsy-proven NAFLD compared with the 'TT' genotype (OR 2.07; 95% CI 1.43-2.01; p=0.018).
Why the study?
Nonalcoholic fatty liver disease is a major global health issue, and the effect of the adiponectin receptor 1 gene polymorphism on NAFLD susceptibility required investigation.
Is the ADIPOR1 rs2275738 polymorphism associated with increased susceptibility to biopsy-proven NAFLD?
Case-Control (n=330)
Is the ADIPOR1 rs2275738 polymorphism associated with increased susceptibility to biopsy-proven NAFLD?
Odds Ratio: 2.07 (95% CI 1.43–2.01)
p-value: p=0.018
The ADIPOR1 rs2275738 'CC' genotype is identified as a genetic marker associated with a 107% increased risk for biopsy-proven NAFLD.
ADIPOR1 rs2275738 CC genotype was associated with NAFLD susceptibility; hypothesis-generating and requires validation before any clinical application.
Aim: Nonalcoholic fatty liver disease (NAFLD) is a significant health issue worldwide. This study investigated the effect of the adiponectin receptor 1 gene (ADIPOR1) polymorphism on susceptibility to NAFLD.Methods: Data from 330 participants, including 165 biopsy-proven NAFLD patients and 165 healthy controls, were collected. The PCR-RFLP method was used to detect the genotypes of ADIPOR1 rs2275738 or T-106C variant.Results: The “CC” genotype of the ADIPOR1 rs2275738 polymorphism, compared with the “TT” genotype and the “C” allele, compared with the “T” allele, are markers of increased NAFLD susceptibility (p = 0.018; OR = 2.07, 95% CI = 1.43–2.01 and p = 0.041; OR = 1.52, 95% CI = 1.24–2.35, respectively).Conclusion: This research suggests, for the first time, that the ADIPOR1 rs2275738 “CC” genotype is associated with a 107% increased risk for biopsy-proven NAFLD.
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Rostami et al. (2024) conducted a case-control in Nonalcoholic fatty liver disease (NAFLD) (n=330). ADIPOR1 rs2275738 'CC' genotype vs. 'TT' genotype was evaluated on Susceptibility to NAFLD (OR 2.07, 95% CI 1.43-2.01, p=0.018). The ADIPOR1 rs2275738 'CC' genotype was associated with a 107% increased risk for biopsy-proven NAFLD compared with the 'TT' genotype (OR 2.07; 95% CI 1.43-2.01; p=0.018).
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