In HeLa cells, multiple infection with poliovirus shortens the eclipse period compared to single particle infection.
Shortens eclipse modeling in cell culture kinetics; leaves open multiplicity effects on poliovirus pathogenesis in vivo.
Studies with polio-infected HeLa cells using cell disruption techniques during the early stages of infection have shown that: The inoculum of poliovirus adsorbed on HeLa cells is largely inactivated. Infective virus accumulates in a monolayer sheet of cells in advance of release into the medium. The eclipse period is shorter in multiply infected cells than in those infected with a single particle.
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James Darnell (1958) studied this question.
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