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April 1, 1973Journal of VirologyOpen Access

Virus Replication, Cytopathology, and Lysosomal Enzyme Response of Mitotic and Interphase Hep-2 Cells Infected with Poliovirus

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Population

Mitotic Hep-2 cells and interphase, random-growing Hep-2 cells

Comparison

Infection with poliovirus type I (Mahoney) vs Interphase, random-growing Hep-2 cells

Design

Preclinical

Authors

KBKurt BienzUniversity of BaselDEDenise EggerUniversity of BernDWDavid WolffAugusta University

Discussion

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Implication

Poliovirus replication proceeds without cytopathic effects or lysosomal redistribution in mitotic cells; leaves open mechanistic requirements for viral release in vivo.

Structured PICO

P
Population
Mitotic Hep-2 cells (selected by the PEL density gradient method and held in mitosis with Colcemid) and interphase, random-growing Hep-2 cells
I
Intervention
Infection with poliovirus type I (Mahoney)
C
Comparator
Interphase, random-growing Hep-2 cells
O
Outcome
Virus replication, cytopathic effect, and lysosomal enzyme responsesurrogate

The study demonstrates that poliovirus synthesis and release in Hep-2 cells is not dependent on cytopathic effect or lysosomal enzyme release.

Cite This Study

Bienz et al. (1973) studied this question.

synapsesocial.com/papers/6a8500c32ef56d2c2c9ea819https://doi.org/10.1128/jvi.11.4.565-574.1973
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON HELA CELL CULTURES EXPOSED TO SPINDLE INHIBITORS WITH SPECIAL REFERENCE TO THE INTERPHASE CELL1964 · 251 citations