What is the clinical evidence from this study?

Study design: Other. Population: Poliomyelitis virus infection (in vitro). Intervention: Types 1 or 2 poliomyelitis virus. Primary outcome: Cellular lesion development and virus release mechanism.

What does this research mean for the field?

Infection of human fibroblasts with poliomyelitis virus causes the formation of a central dense cytoplasmic mass accompanied by marginal bubbling and vacuolization, providing a potential mechanism for virus release prior to complete cell death. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1955Experimental Biology and Medicine

Phase Contrast Cinematography of Cellular Lesion Produced by Poliomyelitis Virus in vitro

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Key result

Poliovirus infection of human fibroblasts produces cytoplasmic masses and marginal bubbling, suggesting early virus release.

Population

Cultures of adult, human fibroblasts of relatively large size and high resistance to nonspecific degeneration

Design

Preclinical

Authors

GBG BarskiInstitut Gustave Roussy RRR RobineauxUniversité Claude Bernard Lyon 1 MEMiyoko EndoUniversity of Tokyo Hospital

Discussion

Member takes

Implication

Cytoplasmic changes may indicate pre-lytic polio release in fibroblasts; leaves open in vivo relevance and therapeutic implications.

Structured PICO

Population

In vitro cultures of adult human fibroblasts infected with Types 1 or 2 poliomyelitis virus.

Intervention

Infection with Types 1 or 2 poliomyelitis virus

Outcome

Cellular lesion development and morphological changes observed by phase contrast microcinematography

In vitro observation of polio-infected human fibroblasts reveals specific cytoplasmic changes and marginal bubbling that may represent a mechanism for viral release before cell death.

Cite This Study

Barski et al. (1955) studied Poliomyelitis virus infection (in vitro). Types 1 or 2 poliomyelitis virus was evaluated on Cellular lesion development and virus release mechanism. Infection of human fibroblasts with poliomyelitis virus produced a central dense mass in the cytoplasm and marginal bubbling, suggesting a mechanism for virus release before cell death.

synapsesocial.com/papers/6aa709d63a3f92caa71b322f https://doi.org/10.3181/00379727-88-21491

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January 1, 1955Experimental Biology and Medicine

Phase Contrast Cinematography of Cellular Lesion Produced by Poliomyelitis Virus in vitro

View Full Paper

Ask AI

Bookmark

Key result

Poliovirus infection of human fibroblasts produces cytoplasmic masses and marginal bubbling, suggesting early virus release.

Population

Cultures of adult, human fibroblasts of relatively large size and high resistance to nonspecific degeneration

Design

Preclinical

Authors

GBG BarskiInstitut Gustave Roussy RRR RobineauxUniversité Claude Bernard Lyon 1 MEMiyoko EndoUniversity of Tokyo Hospital

Discussion

Member takes

Implication

Cytoplasmic changes may indicate pre-lytic polio release in fibroblasts; leaves open in vivo relevance and therapeutic implications.

Structured PICO

Population

In vitro cultures of adult human fibroblasts infected with Types 1 or 2 poliomyelitis virus.

Intervention

Infection with Types 1 or 2 poliomyelitis virus

Outcome

Cellular lesion development and morphological changes observed by phase contrast microcinematography

In vitro observation of polio-infected human fibroblasts reveals specific cytoplasmic changes and marginal bubbling that may represent a mechanism for viral release before cell death.

Cite This Study

synapsesocial.com/papers/6aa709d63a3f92caa71b322f https://doi.org/10.3181/00379727-88-21491

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