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May 25, 1958The Journal of Cell BiologyOpen Access

Fine Structure of Changes Produced in Cultured Cells Sampled at Specified Intervals During a Single Growth Cycle of Polio Virus

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Population

Primary suspended cultures of rhesus monkey kidney cells

Design

Preclinical

Follow-up

up to 7+ hours after adsorption

Authors

FKFrances KallmanRockefeller FoundationRWRobley C. WilliamsUniversity of Nebraska–LincolnRDRenato DulbeccoUniversity of Siena

Discussion

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Implication

Cell morphology stages track poliovirus release in vitro; leaves open in vivo relevance and particle identification.

Structured PICO

P
Population
Primary suspended cultures of rhesus monkey kidney cells
I
Intervention
Infection with poliomyelitis virus, type 1 (Brunhilde strain)
O
Outcome
Correlation of virus release over a one-step growth curve with changes in fine structure as seen in the electron microscopesurrogate

Infection of rhesus monkey kidney cells with poliovirus produces synchronous morphological changes that correlate with the rate of virus release.

Cite This Study

Kallman et al. (1958) studied this question.

synapsesocial.com/papers/6a7652fb889e205583b1bf42https://doi.org/10.1083/jcb.4.3.301
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytopathogenic Effect of Poliomyelitis Viruses In vitro on Human Embryonic Tissues.1950 · 81 citations
  2. 2SEQUENCE OF MORPHOLOGICAL CHANGES IN EPITHELIAL CELL CULTURES INFECTED WITH POLIOVIRUS1956 · 94 citations
  3. 3CELLULAR DIFFERENTIATION IN THE KIDNEYS OF NEWBORN MICE STUDIED WITH THE ELECTRON MICROSCOPE1957 · 406 citations