Why the study?
Does immune serum prevent cytopathology in HeLa cells persistently infected with poliomyelitis virus?
Population
HeLa cells infected with Type III poliomyelitis virus
Comparison
Serum from individuals with previous experience… vs Serum containing no antibodies to poliomyelitis…
Design
Preclinical
Follow-up
prolonged observation
Authors
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May guide non-sterilizing immunity strategies in persistent infections; leaves open in vivo relevance and clinical translation.
Does immune serum prevent cytopathology in HeLa cells persistently infected with poliomyelitis virus?
Immune serum can inhibit the cytopathogenic effect of poliomyelitis virus in HeLa cells without eliminating the persistent infection.
Ackermann et al. (1955) studied this question.
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