Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension

Anesthetized dogs undergoing isotonic saline volume expansion (5% body weight over 60 min)

Nitric oxide synthesis inhibition with NG-nitro-L-arginine methyl ester (L-NAME) (10 micrograms/kg/min i.v.), cyclooxygenase inhibition with meclofenamate (Meclo; 5 mg/kg i.v. bolus), or a combination of both drugs (L-NAME + Meclo)

Control dogs receiving volume expansion alone

Hemodynamic (mean arterial pressure) and natriuretic responses to volume expansionsurrogate