Key result
Symptomatic status in patients with moderately dysfunctional bicuspid aortic valves was associated with a significantly lower rate of event-free survival over an 8-year follow-up period (54% vs. 68%, p=0.001).
Why the study?
Does symptomatic status predict adverse clinical outcomes in patients with moderately dysfunctional bicuspid aortic valves?
Cohort (n=127)
No
Does symptomatic status predict adverse clinical outcomes in patients with moderately dysfunctional bicuspid aortic valves?
Absolute Event Rate: 54% vs 68%
p-value: p=0.001
In patients with moderately dysfunctional bicuspid aortic valves, symptomatic status is driven by moderate aortic stenosis, aortopathy, and diastolic dysfunction, and is associated with significantly worse event-free survival.
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Symptomatic moderate BAV dysfunction may warrant closer surveillance; leaves open whether symptoms independently predict events or justify earlier intervention.
Lee et al. (2017) conducted a cohort in Moderately dysfunctional bicuspid aortic valves (n=127). Symptomatic status vs. Asymptomatic status was evaluated on Event-free survival (composite of aortic valve surgery, hospitalization for heart failure, and any cause of death) (p=0.001). Symptomatic status in patients with moderately dysfunctional bicuspid aortic valves was associated with a significantly lower rate of event-free survival over an 8-year follow-up period (54% vs. 68%, p=0.001).
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