April 2, 2013Current Opinion in Cardiology
Heart rate and heart failure
Key result
Elevated resting heart rate is a key indicator of adverse outcomes in heart failure, and heart rate reduction with agents like ivabradine improves cardiovascular outcomes.
Why the study?
Does heart rate reduction improve cardiovascular outcomes in patients with heart failure?
Population
Patients with heart failure (including systolic heart failure)
Design
Review
Authors
Discussion
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Member takes
Implication
Warrants monitoring heart rate in HF; leaves open optimal agents and populations pending prospective trials.
Structured PICO
Does heart rate reduction improve cardiovascular outcomes in patients with heart failure?
P
Population
Patients with heart failure (including systolic heart failure)
I
Intervention
Heart rate reducing agents (beta-blockers, cardiac glycosides, calcium antagonists, ivabradine)
O
Outcome
Mortality risk and cardiovascular outcomeshard clinical
Elevated resting heart rate is a key indicator of adverse outcomes in heart failure and represents a major treatment target.
Cite This Study
Reil et al. (2013) conducted a review in Heart failure. Heart rate reduction (e.g., ivabradine, β-blockers) was evaluated on Cardiovascular outcomes and mortality risk. Elevated resting heart rate is a key indicator of adverse outcomes in heart failure, and heart rate reduction with agents like ivabradine improves cardiovascular outcomes.