Key result
A family history of essential hypertension in normotensive offspring was associated with lower baseline (67 vs 79, p=0.008) and maximum (74 vs 93, p<0.0005) skin capillary density.
Why the study?
Is a family history of essential hypertension associated with reduced skin capillary density in normotensive individuals?
Population
42 normotensive individuals, comprising 21 subjects with one or both parents having essential hypertension…
Comparison
Family history of essential hypertension vs No family history of essential hypertension
Design
Cross-sectional
Authors
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Hypothesis-generating for capillary rarefaction preceding hypertension; prospective studies needed before clinical adoption.
Cross-Sectional (n=42)
Is a family history of essential hypertension associated with reduced skin capillary density in normotensive individuals?
Absolute Event Rate: 67% vs 79%
p-value: p=0.008
Capillary rarefaction is present in normotensive individuals with a family history of essential hypertension, suggesting it may be a primary structural abnormality that precedes the onset of sustained high blood pressure.
Tarek Antonios (2003) conducted a cross-sectional in Normotension (n=42). Family history of essential hypertension vs. No family history of hypertension was evaluated on Baseline skin capillary density (capillaries per field) (p=0.008). A family history of essential hypertension in normotensive offspring was associated with lower baseline (67 vs 79, p=0.008) and maximum (74 vs 93, p<0.0005) skin capillary density.
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