February 1, 1994Journal of Neurochemistry

Endothelin‐1 Receptor Binding and Cellular Signal Transduction in Cultured Human Brain Endothelial Cells

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Population

Cultured human brain endothelial cells (HBECs)

Design

Preclinical

Authors

DSDanica StanimirovicNational Research Council Canada TYToshifumi YamamotoTokyo Metropolitan Institute of Medical Science SUSumio UematsuNational Institutes of Health

Discussion

Member takes

Implication

Does not yet inform ETA antagonist use in cerebrovascular disease; leaves open translation of endothelial ET-1–PLC coupling to in vivo models.

Structured PICO

Population

Cultured human brain endothelial cells (HBECs)

Intervention

Endothelins (ET-1, ET-2, ET-3, and sarafotoxin S6b), ETA receptor antagonist BQ123, phorbol myristate ester, and pertussis toxin

Outcome

Kinetic properties of endothelin-1 (ET-1) binding sites and production of inositol phosphates (IP1, IP2, IP3), cyclic AMP, thromboxane B2, and prostaglandin F2 alphasurrogate

This study demonstrates that ET-1 (ETA-type) receptors are linked to phospholipase C and phospholipase A2 activation in human brain endothelial cells.

Cite This Study

Stanimirovic et al. (1994) studied this question.

synapsesocial.com/papers/6a8b1e31eada60f85de3b493 https://doi.org/10.1046/j.1471-4159.1994.62020592.x

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Implication

Does not yet inform ETA antagonist use in cerebrovascular disease; leaves open translation of endothelial ET-1–PLC coupling to in vivo models.

Endothelin‐1 Receptor Binding and Cellular Signal Transduction in Cultured Human Brain Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endothelin‐1 Receptor Binding and Cellular Signal Transduction in Cultured Human Brain Endothelial Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider