Key result
Dyslipidemia was strongly associated with coronary heart disease in post-menopausal (aOR 3.018; 95% CI 2.102-4.332) and pre-menopausal (aOR 6.938; 95% CI 1.835-26.224) Lebanese women.
Why the study?
Women are increasingly affected by coronary heart disease with distinct risk-factor peculiarities, but risk factors in Lebanese women over forty remained to be assessed.
What are the risk factors associated with coronary heart disease in Lebanese women over forty?
Case-Control (n=1,500)
Yes
What are the risk factors associated with coronary heart disease in Lebanese women over forty?
Odds Ratio: 3.018 (95% CI 2.102–4.332)
Traditional risk factors such as dyslipidemia, hypertension, family history, and smoking are strongly associated with CHD in Lebanese women, emphasizing the importance of targeted preventive measures.
Identifies modifiable CHD risks in Lebanese women; leaves open whether targeted interventions improve outcomes in this population.
Purpose: Women are increasingly concerned by coronary heart disease (CHD), with peculiarities of their own, particularly concerning risk factors. The aim of the study was to assess the risk factors for CHD in Lebanese women over forty. Patients and Methods: A case-control study was carried out in 6 hospitals in Beirut and Mount-Lebanon, from December 2018 to December 2019 including 1500 patients (1200 controls and 300 cases). Women were stratified into pre- and post-menopausal groups. Personal and medical data were collected from hospital records and during an interview where validated questionnaires were used. Binary logistic regressions were performed to investigate potential predictors of CHD in the 2 groups. Results: In post-menopausal women, dyslipidemia (adjusted odds ratio [aOR], 3.018; 95% confidence interval, 2.102-4.332), hypertension (aOR: 2.449, [1.386-4.327]), a family history of CHD (aOR: 2.724, [1.949-3.808]), cigarette smoking (aOR: 2.317, [1.574-3.410]) and common non-rheumatic joint pain (aOR: 1.457, [1.053-2.016]) were strongly associated with CHD. Conversely, living in Mount Lebanon seemed protective, compared to Beirut (aOR: 0.589, [0.406-0.854]), as well as having a moderate monthly income (aOR: 0.450, [0.220-0.923]), adhering to a Mediterranean diet (aOR: 0.965, [0.936-0.994]), and practicing physical activity [PA] (aOR: 0.396, [0.206-0.759] and 0.725, [0.529-0.992], respectively for high and moderate vs low PA). In pre-menopausal women, dyslipidemia (aOR: 6.938, [1.835-26.224]), hypertension (aOR: 6.195, [1.318-29.119]), family histories of dyslipidemia (aOR: 6.143, [1.560-24.191]) and CHD (aOR: 4.739, [1.336-16.805]) reached statistical significance. Conclusion: The identification of factors associated with CHD in women, some of which are frequent and trivialized in post-menopause, underlines the need to put in place specific and dedicated CHD prevention strategies in women.
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A 2022 study conducted a case-control in Coronary Heart Disease (n=1,500). Cardiovascular risk factors (e.g., dyslipidemia) vs. Absence of risk factors was evaluated on Coronary heart disease (aOR 3.018, 95% CI 2.102-4.332). Dyslipidemia was strongly associated with coronary heart disease in post-menopausal (aOR 3.018; 95% CI 2.102-4.332) and pre-menopausal (aOR 6.938; 95% CI 1.835-26.224) Lebanese women.
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