Why the study?
Does captopril antagonize the hypotensive action of atrial natriuretic peptide in anaesthetized rats?
Does captopril antagonize the hypotensive action of atrial natriuretic peptide in anaesthetized rats?
Answers are grounded in this paper and cite their sources.
ANP exerts its hypotensive action in the anaesthetized rat by antagonizing the vasoconstrictor action of endogenous angiotensin II.
Atrial natriuretic peptide (8-33; ANP) caused a prolonged hypotensive response following intravenous injection in anaesthetized rats. This response was abolished by captopril treatment and restored by concomitant angiotensin II infusion. These results suggest that ANP exerts its hypotensive action in the anaesthetized rat by the antagonism of the vasoconstrictor action of endogenous angiotensin II.
No takes yet. Share an insight, caveat, or question.
Nicolantonio et al. (1986) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: