Why the study?
Does acute administration of captopril reduce mean arterial blood pressure and proximal tubular fluid reabsorption in normotensive and hypertensive rats?
Population
Anaesthetized normotensive rats and two-kidney, one-clip Goldblatt hypertensive rats
Comparison
Acute administration of captopril vs Baseline (pre-administration)
Design
Preclinical
Follow-up
acute
Authors
Loading...
Rat findings do not guide human therapy; leaves open whether angiotensin II effects on proximal reabsorption translate clinically.
Does acute administration of captopril reduce mean arterial blood pressure and proximal tubular fluid reabsorption in normotensive and hypertensive rats?
Acute captopril administration demonstrates that angiotensin II contributes similarly to proximal fluid reabsorption in both normotensive and hypertensive rats.
Harris et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: