Why the study?
Do Angiotensin-II receptor blockers (ARBs) provide benefit as an alternative or addition to ACE inhibitors in patients with heart failure?
Do Angiotensin-II receptor blockers (ARBs) provide benefit as an alternative or addition to ACE inhibitors in patients with heart failure?
ARBs are an attractive alternative for heart failure patients intolerant to ACE inhibitors, but adding them to ACE inhibitors does not appear to provide additional benefits.
Authors
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Adding ARBs to ACE-Is provides no confirmed benefit in HF; leaves open optimal RAAS inhibition strategies.
Jodie M. Fink (2002) studied this question.